Ms Yoon Sook Yee

Procedure Focus:

• Cancer genetic testing

Condition Treated:

• Cancer genetic counselling

Memberships & Associations:

• Genetic Counselling Society Malaysia (GCSM)
• Professional Society of Genetic Counsellors Asia (PSGCA)  
• Human Genetics Society Australasia (HGSA) 
• International Meeting of Psychosocial  Aspects of Hereditary Cancers (IMPAHC)

Post Graduate Qualifications:

• Grad. Dip Genetic Counselling (Aust), FHGSA

Media & Publications:

• Sook-Yee Yoon, Siu Wan Wong, Joanna Lim ……Meow Keong Thong, Yin-Ling Woo, Soo-Hwang Teo (2021). Oncologist-led BRCA counselling improves access to cancer genetic testing in middle-income Asian country, with no significant impact on psychosocial outcomes. Journal of Medical Genetics doi: 10.1136/jmedgenet-2020-107416doi
• Leila Dorling, Sara Carvalho, Jamie Allen…..Sook-Yee Yoon…..  Soo H. Teo, Peter Devilee, Douglas F. Easton (2021) Breast Cancer Risk Genes Association Analysis in More than 113,000 Women. New England Journal of Medicine.384:428-439 doi : 10.1056 
• Hamizah Sa’at, Yew-Kong Lee, Sook-Yee Yoon, Siu-Wan Wong, Yin-Ling Woo, Kristine Barlow-Stewart, Nur Aishah Mohd Taib (2021). The needs of Southeast Asian BRCA mutation carriers considering risk-reducing salpingo-oophorectomy: a qualitative study. Familial Cancer doi: 10.1007/s10689-021-00232-6 
• Weang-Kee Ho, Min-Min Tan, Nasim Mavaddat, …. Sook-Yee Yoon …. Douglas F. Easton, Soo-Hwang Teo & Antonis C. Antoniou  (2020). European polygenic risk score for prediction of breast cancer shows similar performance in Asian women. Nature Communications  doi: 10.1038/s41467-020-17680- 
• Daphne Shin-Chi Lee, Bettina Meiser, Shivaani Mariapun, Tiara Hassan, Cheng-Har Yip, Nur Aishah Mohd Taib, Soo-Hwang Teo, Meow-Keong Thong, Sook-Yee Yoon. Communication about positive BRCA1 and BRCA2 genetic test results and uptake of testing in relatives in a diverse Asian setting. (2020). Journal of Genetic Counselling. 
• Patel, V. L., Busch, E. L., Friebel, T. M., Cronin, A., Leslie, G., McGuffog. . . . . . . .  L., …Yoon, S. Y., . . . Rebbeck, T. R. (2019). Association of Genomic Domains in BRCA1 and BRCA2 with Prostate Cancer Risk and Aggressiveness. Cancer Res. doi: 10.1158/0008-5472.can-19-1840 
• Abacan, M., Alsubaie, L., Barlow-Stewart, K., Caanen, B., Cordier, C., Courtney, E., …Yoon, S. Y.,. . . Wicklund, C. (2019). The Global State of the Genetic Counseling Profession. Eur J Hum Genet, 27(2), 183-197. doi: 10.1038/s41431-018-0252-x 
• Yang, X., Leslie, G., Doroszuk, A., Schneider, S., Allen, J., Decker, B., …Yoon, S. Y.,. . . Tischkowitz, M. (2019). Cancer Risks Associated With Germline PALB2 Pathogenic Variants: An International Study of 524 Families. J Clin Oncol, JCO1901907. doi: 10.1200/jco.19.01907 
• Wen, W. X., Allen, J., Lai, K. N., Mariapun, S., Hasan, S. N., Ng, P. S., …Yoon, S. Y., . . . Teo, S. H. (2018). Inherited mutations in BRCA1 and BRCA2 in an unselected multiethnic cohort of Asian patients with breast cancer and healthy controls from Malaysia. J Med Genet, 55(2), 97-103. doi: 10.1136/jmedgenet-2017-104947 
• Tan, M. M., Ho, W. K., Yoon, S. Y., Mariapun, S., Hasan, S. N., Lee, D. S., Hassan, T.,. . . Teo, S. H. (2018). A case-control study of breast cancer risk factors in 7,663 women in Malaysia. PLoS One, 13(9), e0203469. doi: 10.1371/journal.pone.0203469 
• Rebbeck, T. R., Friebel, T. M., Friedman, E., Hamann, U., Huo, D., Kwong, A., …Yoon, S. Y., . . . Nathanson, K. L. (2018). Mutational spectrum in a worldwide study of 29,700 families with BRCA1 or BRCA2 mutations. Hum Mutat, 39(5), 593-620. doi: 10.1002/humu.23406 
• Lim, K. K., Yoon, S. Y., Mohd Taib, N. A., Shabaruddin, F. H., Dahlui, M., Woo, Y. L.,… Yoon, S. Y., . . . Chaiyakunapruk, N. (2018). Is BRCA Mutation Testing Cost Effective for Early Stage Breast Cancer Patients Compared to Routine Clinical Surveillance? The Case of an Upper Middle-Income Country in Asia. Appl Health Econ Health Policy, 16(3), 395-406. doi: 10.1007/s40258-018-0384-8 
• Lecarpentier, J., Silvestri, V., Kuchenbaecker, K. B., Barrowdale, D., Dennis, J., McGuffog, L., …Yoon, S. Y., . . . Ottini, L. (2017). Prediction of Breast and Prostate Cancer Risks in Male BRCA1 and BRCA2 Mutation Carriers Using Polygenic Risk Scores. J Clin Oncol, 35(20), 2240-2250. doi: 10.1200/jco.2016.69.4935 
•  Silvestri, V., Barrowdale, D., Mulligan, A. M., Neuhausen, S. L., Fox, S., Karlan, B. Y.,… Yoon, S. Y., . . . Ottini, L. (2016). Male breast cancer in BRCA1 and BRCA2 mutation carriers: pathology data from the Consortium of Investigators of Modifiers of BRCA1/2. Breast Cancer Res, 18(1), 15. doi: 10.1186/s13058-016-0671-y 
• Meeks, H. D., Song, H., Michailidou, K., Bolla, M. K., Dennis, J., Wang, Q., . .. Yoon, S. Y.,… Goldgar, D. E. (2016). BRCA2 Polymorphic Stop Codon K3326X and the Risk of Breast, Prostate, and Ovarian Cancers. J Natl Cancer Inst, 108(2). doi: 10.1093/jnci/djv315 
• Lawrenson, K., Kar, S., McCue, K., Kuchenbaeker, K., Michailidou, K., Tyrer, J., . . . Yoon, S. Y.,… Gayther, S. A. (2016). Functional mechanisms underlying pleiotropic risk alleles at the 19p13.1 breast-ovarian cancer susceptibility locus. Nat Commun, 7, 12675. doi: 10.1038/ncomms12675 
• Dunning, A. M., Michailidou, K., Kuchenbaecker, K. B., Thompson, D., French, J. D., Beesley, J., . . . Yoon, S. Y.,..Edwards, S. L. (2016). Breast cancer risk variants at 6q25 display different phenotype associations and regulate ESR1, RMND1 and CCDC170. Nat Genet, 48(4), 374-386. doi: 10.1038/ng.3521 
• Kang, P. C., Phuah, S. Y., Sivanandan, K., Kang, I. N., Thirthagiri, E., Liu, J. J., . . . Yoon, S. Y.,…Teo, S. H. (2015). Erratum to: recurrent mutation testing of BRCA1 and BRCA2 in Asian breast cancer patients identify carriers in those with presumed low risk by family history. Breast Cancer Res Treat, 150(3), 699-700. doi: 10.1007/s10549-015-3360-0 
• Kang, P. C., Phuah, S. Y., Sivanandan, K., Kang, I. N., Thirthagiri, E., Liu, J. J., . . . Yoon, S. Y.,…Teo, S. H. (2014). Recurrent mutation testing of BRCA1 and BRCA2 in Asian breast cancer patients identify carriers in those with presumed low risk by family history. Breast Cancer Res Treat, 144(3), 635-642. doi: 10.1007/s10549-014-2894-x 
• Phuah, S. Y., Lee, S. Y., Kang, P., Kang, I. N., Yoon, S. Y., Thong, M. K., . . . Teo, S. H. (2013). Prevalence of PALB2 mutations in breast cancer patients in multi-ethnic Asian population in Malaysia and Singapore. PLoS One, 8(8), e73638. doi: 10.1371/journal.pone.0073638 
• Lee, D. S., Yoon, S. Y., Looi, L. M., Kang, P., Kang, I. N., Sivanandan, K., . . . Teo, S. H. (2012). Comparable frequency of BRCA1, BRCA2 and TP53 germline mutations in a multi-ethnic Asian cohort suggests TP53 screening should be offered together with BRCA1/2 screening to early-onset breast cancer patients. Breast Cancer Res, 14(2), R66. doi: 10.1186/bcr3172 
• Yoon, S. Y., Thong, M. K., Taib, N. A., Yip, C. H., & Teo, S. H. (2011). Genetic counseling for patients and families with hereditary breast and ovarian cancer in a developing Asian country: an observational descriptive study. Fam Cancer, 10(2), 199-205. doi: 10.1007/s10689-011-9420-7 
• Kang, P., Mariapun, S., Phuah, S. Y., Lim, L. S., Liu, J., Yoon, S. Y., . . . Teo, S. H. (2010). Large BRCA1 and BRCA2 genomic rearrangements in Malaysian high risk breast-ovarian cancer families. Breast Cancer Res Treat, 124(2), 579-584. doi: 10.1007/s10549-010-1018-5 
• Toh, G. T., Kang, P., Lee, S. S., Lee, D. S., Lee, S. Y., Selamat, S., . . . Yoon, S. Y.,…Teo, S. H. (2008). BRCA1 and BRCA2 germline mutations in Malaysian women with early-onset breast cancer without a family history. PLoS One, 3(4), e2024. doi: 10.1371/journal.pone.0002024