Pituitary Adenomas

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What Are Pituitary Adenomas?

Pituitary adenomas are noncancerous (benign) tumors that occur in the pituitary gland, a small gland located at the base of the brain. The pituitary gland produces hormones that regulate important body functions. While most pituitary adenomas are benign and slow-growing, they can affect hormone levels and cause a variety of symptoms.

Symptoms of Pituitary Adenomas

Symptoms depend on the tumor’s size and which hormones are affected. Common symptoms include:

  • Headaches
  • Vision problems (often from pressure on the optic nerves), including loss of side vision or blurry vision
  • Hormone-related conditions:
    • Cushing’s disease (excess cortisol)
    • Acromegaly (excess growth hormone)
    • Prolactinoma (excess prolactin)
  • Fatigue
  • Weight changes
  • Irregular menstrual periods or erectile dysfunction.

Causes

The exact cause is often unknown. Factors linked to a higher likelihood include:

  • Genetic syndromes (rare): e.g., MEN1, Carney complex, AIP mutation–related familial isolated pituitary adenomas
  • Prior head irradiation (rare, delayed risk)
  • Most cases are sporadic and not inherited or preventable

If you have a family history of endocrine tumors, an endocrinologist can advise whether genetic counseling/testing is appropriate.

When to Seek Medical Advice

  • New/worsening headaches or vision changes
  • Unexplained menstrual irregularity, infertility, low libido, erectile dysfunction
  • Signs of Cushing’s disease, acromegaly, or symptoms suggestive of a prolactinoma
  • Symptoms of sudden severe headache with vision loss (possible pituitary apoplexy): seek urgent care or go to the nearest Emergency Department

At Subang Jaya Medical Centre (SJMC), our multidisciplinary team led by experienced endocrinologists and skull base neurosurgeons provides comprehensive care for pituitary adenomas with state-of-the-art MRI, targeted hormone testing, and tailored treatments. Call or book your appointment today to clarify your symptoms, confirm your diagnosis, and choose the best plan for you.


FAQs About Pituitary Adenomas Symptoms and Causes

A pituitary adenoma is a type of pituitary tumour. It’s the most commonly identified pituitary growth and doctors describe it by size: a microadenoma is under 10 mm and a macroadenoma is 10 mm or more. Most pituitary tumours are adenomas and are non-cancerous (benign).

No. They are benign (non-cancerous) tumours. They can still cause problems by changing hormone levels or pressing on nearby structures.

For most people, the cause is unknown. Lifestyle and environment don’t appear to raise risk. A small minority are linked to inherited conditions such as MEN1/MEN4, Carney complex, or McCune–Albright syndrome.

No. Some small tumours cause no symptoms and are found incidentally. Others cause symptoms from pressure or hormone over/under-production.

If you have the symptoms above or a scan has mentioned a pituitary lesion, ask for a referral to an endocrinologist (and, if needed, a skull base neurosurgeon).

References

  1. Pituitary Network Association
  2. American Association of Neurological Surgeons
  3. Mayo Clinic